Presenting our work from Cajal Neuroscience about disease trajectory inference in Alzheimer’s disease at ADPD2023. This year was very stimulating meeting of nearly 4000 scientists, medical doctors and biotech companies. There have been numerous sections on various aspects of neurodegeneration. I have presented our results on the analysis of human cortical data in genetics of Alzheimer's disease section. It is very encouraging to see so many researchers working on the same problems. I firmly believe that together we could find better drugs and develop new therapies to stop neurodegeneration.